ABSTRACT

The chemical structure of thiamine is shown in Figure 1. A pyrimidine moiety (2methyl4-amino-5-hydroxymethylpyrimidine) and a thiazole moiety (4-methyl5hydroxyethylthiazole) are connected by a methylene group. The double-salt form of thiamine with hydrochloric acid (C12H17N4OSCl-HCl; molecular weight 337.28) is readily soluble in water, less soluble in methanol and glycerol, nearly insoluble in ethanol, and insoluble in ether and benzene (1).