We began this book with the FBI’s removal of “spree killer” from the multicide classifications, citing its lack of utility for law enforcement. In cases such as random spree killing, or the categories of Movement in Tight Locations and Robbery/Thrill, the Bureau is correct. Unless there is a way to anticipate where and when a killer might strike via specific locations, business activities, and victim associations, responders cannot plan or gather resources for best effect. In this chapter, we address some of the key issues in responding to a spree, as well as offer some tips gleaned from the cases we’ve presented and analyzed in prior chapters.