ABSTRACT
Basic genomics research has been conducted on many levels to implement personalized, preventive medicine: finding druggable targets in the genome through pharmacogenetics research, finding genetic polymorphisms through genome-wide association studies (GWAS) and the haplotype map project; the discovery of clinical biomarkers for disease and illness; and the discovery of somatic mutations harbored by tumors. GWAS paved the way for personalized medicine to detect variants associated with diseases. The University of Arizona (UA) Health Sciences seeks to establish a healthcare delivery platform with clinical partners that individualizes healthcare by incorporating "omics" approaches into clinical diagnosis and treatment, patient stratification, and clinical management, with improvements in individual and population health, while reducing healthcare costs. UA precision health strategies include genome-based evaluations for increased diagnostic precision, targeted therapies that improve pharmacological efficacy and decrease toxicity, and optimized clinical management based on omics stratification and molecular diagnostics.
