This chapter focuses on both past and present attempts by the Muslim Brotherhood to address the more existential issue of Muslim unity under its own organizational banner regionally and globally. It examines past founding of regional branches and regional relations in the 1940s and 1950s, as well as commitment to universal Islamist causes such as the Palestinian issue. The chapter also examines the ways in which, in the twenty-first century, the Muslim Brotherhood has embraced transnational technologies in pursuit of a global Brotherhood enjoined in the same ideological goals. It explores the limits of the Ikhwan project, historically bounded by the nation-state in the Middle East and the distinct national manifestations of the Brotherhood as a counteranalysis to the fear and threat of a region increasingly dominated and governed by the Islamists of the Brotherhood. The chapter presents the global consequences of this resurgence in terms of strategic and security policy and counterterrorism agendas.