Entrepreneurship is vital to achieving United Nations Sustainable Development Goals (SDGs) 4 and 8. SGD 4 ensures inclusive and equitable quality education that promotes lifelong learning opportunities for all. SDG 8 promotes sustained inclusive and sustainable economic growth. The Kwawu complex and resilient entrepreneurial ecosystem is a vital means by which lifelong learning, social and economic goals are achieved. This article examines the nature of the resilient entrepreneurial ecosystem among the people of Kwawu in Ghana through the lens of complexity science. Previous studies have recognised technology as the main driving force behind entrepreneurial ecosystems across regions/countries. However, an in-depth discussion on how social learning systems and communities of practices foster entrepreneurial ecosystems, has received scant attention in the research literature. The article contributes towards filling this gap by highlighting how the Kwawu people have nurtured a resilient entrepreneurial ecosystem through a network of agents, community resources, and support systems that help entrepreneurs thrive and succeed. It presents findings on eight (8) elements in an interacting and emergent ecosystem. These are enabling entrepreneurial culture; interdependent learning cycle consisting of six elements - observing, doing, adopting, adapting, replicating, spiriting; and finally, social inclusion.