It has become painfully apparent that Covid-19 may be changing the world that we know and that there is a pressing need to recognise that the “old normal” was never normal. Socioeconomic, geopolitical and environmental conditions should make us reflect on some of the reasons: Africa and India – with over 1 billion people each are excluded as permanent members of the United Nations Security Council (UNSC), a body (US, China, Russia, UK, France) established in 1946 after WWII and still, with the same members making decisions on security and peace for the world, with about 5 billion people (out of c.7.8 billion) excluded from the table. In addition, we are driving species to extinction at about 1000 times baseline rates. Half the vertebrate animals have vanished in the past two generations. We spend more on conflicts and wars (c. USD $13 trillion per year) than on peace, which receives only about USD $ 6 billion annually - with some believing that even that amount is too much. Half the world’s wealth (over USD $300 trillion) belongs to the top 1 per cent of the global population. As we are witnessing across the globe (e.g., US, UK, Venezuela, China), social inequalities and divisions (oligarchies vs democracy) are largely responsible for the growing unrest exacerbated by radical far-right and far-left politics, reminiscent of the 1930s. Prompted by my recent book, Survival: One Health, One Planet, One Future, and the disastrous impact of Covid-19, the two articles, “The World at Risk: Covid-19, Global Sustainability and 1 HOPE” and a follow-up “Postscript” are meant to raise awareness of the unprecedented challenges we face while exploring ways forward toward a “new normal”. One of the key messages is that a “new normal” is only possible if we take on board the One Health and Well-Being concept – recognising the vital interconnections and interdependencies among humans, animals, plants and their shared environment - leading us to responsible decision-making for the common good (vs self-serving), green economies and peace. As US civil rights leader, Martin Luther King Jr stated more than six decades ago-‘Our lives begin to end the day we become silent about things that matter.’ It’s time for us all to have our voices heard!